Persistence of sulfadoxine-pyrimethamine resistance despite reduction of drug pressure in Malawi

In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. This study estimates the effect of reduced SP drug pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci.

Author: , , , , , , , ,
Publication date: February 2015
Source: The Journal of Infectious Diseases