Engaging the private sector in malaria surveillance: a review of strategies and recommendations for elimination settings

To learn more about the role and performance of the private sector in malaria diagnosis, case management, and reporting in malaria elimination settings, 25 experts in malaria elimination, disease surveillance, and private sector engagement were purposively sampled and interviewed. An extensive review of grey and peer-reviewed literature on private sector testing, treatment, and reporting for malaria was performed. Additional in-depth literature review was conducted for six case studies on eliminating and neighbouring countries in Southeast Asia and Southern Africa.

Author: , , , , ,
Publication date: June 2017
Source: Malaria Journal

Eliminate now: seven critical actions required to accelerate elimination of Plasmodium falciparum malaria in the Greater Mekong Subregion

Progress in Southeast Asia is threatened by the emergence of drug resistant parasites and hampered by systemic challenges. This commentary proposes seven concrete actions to address these issues and accelerate malaria elimination in the region.

Author: , , ,
Publication date: October 2016
Source: Malaria Journal

Development of a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine and artemether-lumefantrine to treat Plasmodium falciparum infections in Swaziland: a pilot study

Improved pharmacovigilance to monitor and promote the safety of the WHO recommendation is needed. The successful application of the Primaquine Roll Out Monitoring Pharmacovigilance Tool (PROMPT) demonstrates its potential as an important tool to rapidly generate locally acquired safety data and support pharmacovigilance in resource-limited settings.

Author: , , , , , , , , , , , , , , , ,
Publication date: July 2016
Source: Malaria Journal

Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial

Single low doses of primaquine, when added to artemisinin-based combination therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. A single dose of 0·25 mg/kg primaquine, given alongside dihydroartemisinin–piperaquine, was safe and efficacious for the prevention of P falciparum malaria transmission in boys and men who are not deficient in G6PD

Author: , , , , , , , , , , , , , , , , , , ,
Publication date: June 2016
Source: The Lancet Infectious Diseases

An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa.

This article outlines some of the barriers to single low-dose (SLD) primaquine use to stop P. falciparum transmission. In-country key informants revealed that the WHO weight-based recommendation to use SLD primaquine is challenging to implement in actual field settings, due in part to safety concerns involving G6PD deficiency and drug-drug interactions, among other factors.

Author: , , , , , , , ,
Publication date: May 2015
Source: Malaria Journal

Review of Mass Drug Administration for Malaria and Its Operational Challenges

Despite some substantial knowledge gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in aspecific settings.

Author: , , , , , , , , , , , ,
Publication date: May 2015
Source: AJTMH

Mass Screening and Treatment using a Falciparum-specific Rapid Diagnostic Test did not reduce malaria incidence in Zanzibar.

Seasonal increases in malaria continue in hotspots in Zanzibar. Mass screening and treatment (MSAT) may help reduce the reservoir of infection; however, it is unclear whether rapid diagnostic tests (RDT) detect a sufficient proportion of low-density infections to have impact on subsequent transmission. This study found that highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT an effective strategy in malaria pre-elimination settings.

Author: , , , , , , , , , , , , , ,
Publication date: November 2014
Source: Journal of Infectious Diseases

The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion

Foci of artemisinin drug resistance have been identified in the Greater Mekong subregion (GMS) of the Asia Pacific, threatening the major gains made in malaria control and potentially creating a parasite pool that is more difficult to treat and eliminate. … A sustainable solution is the rapid elimination of all Plasmodium falciparum parasites from the GMS.

Author: , , , , , , ,
Publication date: July 2014
Source: Malaria Journal

Program Management Issues in Implementation of Elimination Strategies

A background paper by the UCSF Global Health Group’s Malaria initiative examining the major enabling factors and roadblocks in the management of malaria elimination activities. The paper discusses how to effectively manage the shift from malaria control to elimination at the national level, borrowing from management techniques used in the private sector.

Author: , , , , , , , , ,
Publication date: January 2014
Source: UCSF Global Health Group Malaria Elimination Initiative

Rationale for short course primaquine in Africa to interrupt malaria transmission

A report of a meeting held in London in March 2012, discussing the existing evidence on the ability of primaquine to block malaria transmission, defining the roadblocks to the use of primaquine in Africa and to developing a roadmap to enable its rapid, safe and effective deployment.

Author: , ,
Publication date: October 2012
Source: Malaria Journal