Estimating the most efficient allocation of interventions to achieve reductions in Plasmodium falciparum malaria burden and transmission in Africa: a modelling study

Reducing the burden of malaria is a global priority, but financial constraints mean that available resources must be allocated rationally to maximise their effect. [This study] aimed to develop a model to estimate the most efficient (ie, minimum cost) ordering of interventions to reduce malaria burden and transmission. [It] also aimed to estimate the efficiency of different spatial scales of implementation.

Author: , , ,
Publication date: June 2016
Source: The Lancet Global Health

Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study

This study used a mathematical model of the transmission of Plasmodium falciparum malaria to explore the potential effect on case incidence and malaria mortality rates from 2015 to 2030 of five different intervention scenarios. These findings show that decreases in malaria transmission and burden can be accelerated over the next 15 years if the coverage of key interventions is increased.

Author: , , , , , , , , , ,
Publication date: April 2016
Source: The Lancet Infectious Diseases

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

This article, published in Nature found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015. Interventions have averted an estimated 663 (542–753 credible interval) million clinical cases since 2000. Insecticide-treated nets, the most widespread intervention, were by far the largest contributor (68% of cases averted).

Author: , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: September 2015
Source: Nature

Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis

The Ebola epidemic in West Africa weakened health systems, threatening the gains in malaria control achieved over the past decade. This article quantified this additional indirect burden of Ebola.

Author: , , , , ,
Publication date: July 2015
Source: The Lancet Infectious Diseases

The Interaction between Seasonality and Pulsed Interventions against Malaria in Their Effects on the Reproduction Number

Malaria and other diseases are often highly seasonal and some interventions have time-varying effects, meaning that simple reproduction number formulae cannot be used. This study expands on existing methods to calculate the effect size of repeated rounds of mass drug administration, indoor residual spraying and other interventions against Plasmodium falciparum malaria in seasonal settings in Africa, determining that the optimal time of year for drug administration is in the low season, whereas the best time for indoor residual spraying or a vaccine which reduces infection rates is just before the high season.

Publication date: January 2015
Source: PLOS Computational Biology