Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised to push a region to elimination. This study uses mathematical modelling to assess how baseline transmission intensity and local interconnectedness affect the impact of reactive activities in the context of other possible intervention packages.

Author: , , , , , , , ,
Publication date: June 2017
Source: Malaria Journal

A framework for evaluating the costs of malaria elimination interventions: an application to reactive case detection in Southern Province of Zambia, 2014

This paper summarizes a framework for evaluating the costs of malaria elimination interventions and applies this approach to one key component of the elimination strategy—reactive case detection (RCD)—implemented through 173 health facilities across 10 districts in Southern Province of Zambia during 2014.

Author: , , , , , ,
Publication date: August 2016
Source: Malaria Journal

A qualitative review of implementer perceptions of the national community-level malaria surveillance system in Southern Province, Zambia

This review highlights the importance of a community surveillance system like RCD in shaping Zambia’s malaria elimination campaign by identifying community-based infections that might otherwise remain undetected. Results from this review will be used to plan programme scale-up into other parts of Zambia.

Author: , , , , , , , ,
Publication date: August 2016
Source: Malaria Journal

Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia’s southern province: a simulation study

The optimal implementation strategy for mass test and treat or mass drug administration malaria parasite clearance strategies will vary by background level of prevalence, by rate of infections imported to the area, and by ability to operationally achieve high population coverage.

Author: , , , ,
Publication date: March 2016
Source: Malaria Journal

Assessing the effectiveness of household-level focal mass drug administration and community-wide mass drug administration for reducing malaria parasite infection prevalence and incidence in Southern Province, Zambia: study protocol for a community randomized controlled trial

The primary aim of this study is to quantify the relative effectiveness of MDA and fMDA with DHAp against no mass treatment (standard of care) for reducing Plasmodium falciparum prevalence and incidence. Strengths of this trial include: a robust study design (CRCT); cross-sectional parasite surveys as well as a longitudinal cohort; and stratification of high and low transmission areas. Primary limitations include: statistical power to detect only a 50 % reduction in primary outcomes within high and low transmission strata; potential for contamination; and potential for misclassification of exposure.

Author: , , , , , , , , , , ,
Publication date: August 2015
Source: Trials Journal

Enhanced surveillance and data feedback loop associated with improved malaria data in Lusaka, Zambia

Enhanced surveillance and implementation of a data feedback loop have substantially increased malaria testing rates and decreased the number of unconfirmed malaria cases and courses of ACT consumed in Lusaka District within just two years.

Author: , , , , , , , , , , ,
Publication date: May 2015

Costs and cost-effectiveness of a large-scale mass testing and treatment intervention for malaria in Southern Province, Zambia

The intervention [mass testing and treatment, MTAT] appears to be highly cost-effective relative to World Health Organization thresholds for malaria burden reduction in Zambia as compared to no MTAT. However, it was estimated that population-wide mass drug administration is likely to be more cost-effective for burden reduction and for transmission reduction compared to MTAT.

Author: , , , , , , , ,
Publication date: May 2015
Source: Malaria Journal

A methodological framework for the improved use of routine health system data to evaluate national malaria control programs: evidence from Zambia

When improved through comprehensive parasitologically confirmed case reporting, HMIS data can become a valuable tool for evaluating malaria program scale-up. Using this approach, this article provides further evidence that increased ITN coverage is associated with decreased malaria morbidity and use of health services for malaria illness in Zambia.

Author: , , , , , , , , , , ,
Publication date: November 2014
Source: Population health metrics