Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood

A mother’s infection with placental malaria (PM) can affect her child’s susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a small amount of maternal cells and DNA known as maternal microchimerism (MMc), and it was hypothesized that PM increases MMc and that MMc alters risk of Plasmodium falciparum malaria during infancy. Here, the presence and level of cord blood MMc in offspring of women with and without PM was evaluated.

Author: , , , , , , ,
Publication date: March 2017
Source: The Journal of Infectious Diseases

Pregnant women are a reservoir of malaria transmission in Blantyre, Malawi

These data suggest that pregnant women are a significant reservoir of gametocyte transmission and should not be overlooked in elimination efforts. Interventions targeting this population would benefit from reaching women prior to first antenatal visit.

Author: , , , , , , ,
Publication date: December 2014
Source: Malaria Journal