Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study

This study used consensus modeling to understand how to optimize the effects of mass drug administration in areas with low malaria transmission.

Author: , , , , , , , , , , , , , , , ,
Publication date: May 2017
Source: The Lancet Global Health

Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa

This article discusses the high potential of the RTS,S vaccine for malaria in children. Additionally, results show that not only will the vaccine likely lead to positive health outcomes, but it is expected to do so in a cost-effective manner.

Author: , , , , ,
Publication date: January 2017
Source: Vaccine

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions, and maintaining their effectiveness in the face of insecticide and drug resistance, should form a cornerstone of post-2015 control strategies.

Author: , , , , , , , , , , , ,
Publication date: September 2015
Source: Nature

Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment

When coverage of effective treatment is taken into account, higher country level estimates of average EIR and thus higher disease burden, are obtained for a given prevalence level, especially where access to treatment is high, and prevalence relatively low. These methods provide a unified framework for comparison of both the immediate and longer-term impacts of case management and of preventive interventions.

Author: , , , , , , ,
Publication date: April 2015

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

This article, published in Nature found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015. Interventions have averted an estimated 663 (542–753 credible interval) million clinical cases since 2000. Insecticide-treated nets, the most widespread intervention, were by far the largest contributor (68% of cases averted).

Author: , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: September 2015
Source: Nature

The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models

Adding RTS,S to existing control programs, assuming continuation of current levels of malaria exposure and of health system performance, will potentially avert 100–580 malaria deaths and 45,000 to 80,000 clinical episodes per 100,000 fully vaccinated children over an initial 10-year phase.

Author: , , , ,
Publication date: July 2015
Source: Bio Med Central