Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised to push a region to elimination. This study uses mathematical modelling to assess how baseline transmission intensity and local interconnectedness affect the impact of reactive activities in the context of other possible intervention packages.
There may be significant potential in a long-acting oral antimalarial. This drug could have consequences for mass drug administration strategies, as well as eventual malaria elimination targets.
Author: Barman R, Bellinger AM, Bensel T, Booth L, Cleveland C, Daily J, Eckhoff PA, Grant TM, Hurowitz HM, Jafari M, Kogan L, Langer R, Lee YL, Mazdiyasni H, Minahan D, Mo S, Nikolic B, Slater HC, Tai T, Traverso G, Wenger EA, Wood L, Zhang S
Publication date: November 2016
Source: Science Translational Medicine
Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions, and maintaining their effectiveness in the face of insecticide and drug resistance, should form a cornerstone of post-2015 control strategies.