Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs).

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Publication date: September 2015
Source: BMC Medicine

Molecular Surveyor K13

The discovery of molecular markers of resistance in the Kelch 13 gene gives us the unusual opportunity to monitor the emergence and spread of resistance nearly in real time. The K13 Molecular Surveyor is an interactive map that summarises the prevalence of these molecular markers in the propeller region of the Kelch 13 gene of the malaria parasite by location and year, providing a clear and standardised visualisation of the evidence to date to inform key international, regional and national monitoring strategies.

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Publication date: May 2015
Source: Worldwide Antimalarial Resistance Network (WWARN)