Imported Plasmodium falciparum and locally transmitted Plasmodium vivax: cross-border malaria transmission scenario in northwestern Thailand

Cross-border malaria transmission is an important problem for national malaria control programs. The epidemiology of cross-border malaria is further complicated in areas where Plasmodium falciparum and Plasmodium vivax are both endemic. By combining passive case detection data with entomological data, a transmission scenario on the northwestern Thai–Myanmar border where P. falciparum is likely driven by importation was described, whereas P. vivax is also locally transmitted. This study highlights the differences in the level of control required to eliminate P. falciparum and P. vivax from the same region.

Author: , , , , , , ,
Publication date: June 2017
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/imported-plasmodium-falciparum-and-locally-transmitted-plasmodium-vivax-cross-border-malaria-transmission-scenario-in-northwestern-thailand/

New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission

Antibodies against Plasmodium falciparum surface protein, Pfs25, are known to block parasite development in the mosquito vector. However, in initial clinical trials the limited immunogenicity of recombinant Pfs25 protein-in-adjuvant vaccines has been a challenge. In this study, Ad5-based vaccine vectors were developed to direct the Pfs25-specific antibody response to relevant, transmission-blocking epitopes.

Author: , , ,
Publication date: June 2017
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/new-adenovirus-based-vaccine-vectors-targeting-pfs25-elicit-antibodies-that-inhibit-plasmodium-falciparum-transmission/

Engaging the private sector in malaria surveillance: a review of strategies and recommendations for elimination settings

To learn more about the role and performance of the private sector in malaria diagnosis, case management, and reporting in malaria elimination settings, 25 experts in malaria elimination, disease surveillance, and private sector engagement were purposively sampled and interviewed. An extensive review of grey and peer-reviewed literature on private sector testing, treatment, and reporting for malaria was performed. Additional in-depth literature review was conducted for six case studies on eliminating and neighbouring countries in Southeast Asia and Southern Africa.

Author: , , , , ,
Publication date: June 2017
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/engaging-the-private-sector-in-malaria-surveillance-a-review-of-strategies-and-recommendations-for-elimination-settings/

Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised to push a region to elimination. This study uses mathematical modelling to assess how baseline transmission intensity and local interconnectedness affect the impact of reactive activities in the context of other possible intervention packages.

Author: , , , , , , , ,
Publication date: June 2017
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/effectiveness-of-reactive-case-detection-for-malaria-elimination-in-three-archetypical-transmission-settings-a-modelling-study/

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial

This manuscript describes the study design and methodology of a cluster-randomized controlled trial to evaluate a mass testing and treatment approach for malaria transmission reduction in an area of high malaria transmission in western Kenya.

Author: , , , , , , , , , , , , , , , , , ,
Publication date: June 2017
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/community-based-intermittent-mass-testing-and-treatment-for-malaria-in-an-area-of-high-transmission-intensity-western-kenya-study-design-and-methodology-for-a-cluster-randomized-controlled-trial/

Using remote sensing environmental data to forecast malaria incidence at a rural district hospital in Western Kenya

Two statistical models,a general additive model (GAM) and GAMBOOST model with boosted regression were contrasted by assessing their predictive accuracy in forecasting malaria admissions at lead times of one to three months. The GAMBOOST model at one-month lead time had the highest predictive skill during both the training and test periods and thus can be utilized in a malaria early warning system.

Author: , , ,
Publication date: June 2017
Source: Scientific Reports
Permalink: http://www.makingmalariahistory.org/toolkit-resource/using-remote-sensing-environmental-data-to-forecast-malaria-incidence-at-a-rural-district-hospital-in-western-kenya/

Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study

This study used consensus modeling to understand how to optimize the effects of mass drug administration in areas with low malaria transmission.

Author: , , , , , , , , , , , , , , , ,
Publication date: May 2017
Source: The Lancet Global Health
Permalink: http://www.makingmalariahistory.org/toolkit-resource/role-of-mass-drug-administration-in-elimination-of-plasmodium-falciparum-malaria-a-consensus-modelling-study/

Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial

A randomized controlled trial in Ethiopia comparing the efficacy and safety of primaquine regimens for radical cure.

Author: , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: May 2017
Source: PLOS Medicine
Permalink: http://www.makingmalariahistory.org/toolkit-resource/comparison-of-artemether-lumefantrine-and-chloroquine-with-and-without-primaquine-for-the-treatment-of-plasmodium-vivax-infection-in-ethiopia-a-randomized-controlled-trial/

Towards the implementation of malaria elimination policy in South Africa: the stakeholders’ perspectives

This article finds stakeholders in South Africa concerned about the malaria elimination policy there, citing “staff attitudes and poor capacity, lack of resources, lack of new effective intervention tools, lack of intra- and inter-departmental collaboration, poor cross-border collaboration and weak stakeholder collaboration.”

Author: ,
Publication date: May 2017
Source: Global Health Action
Permalink: http://www.makingmalariahistory.org/toolkit-resource/towards-the-implementation-of-malaria-elimination-policy-in-south-africa-the-stakeholders-perspectives/

Characterizing and quantifying human movement patterns using GPS data loggers in an area approaching malaria elimination in rural southern Zambia

In areas approaching malaria elimination, human mobility patterns are important in determining the proportion of malaria cases that are imported or the result of low-level, endemic transmission. A convenience sample of participants enrolled in a longitudinal cohort study in the catchment area of Macha Hospital in Choma District, Southern Province, Zambia, was selected to carry a GPS data logger for one month from October 2013 to August 2014. Density maps and activity space plots were created to evaluate seasonal movement patterns. Time spent outside the household compound during anopheline biting times, and time spent in malaria high- and low-risk areas, were calculated.

Author: , , , , , , ,
Publication date: May 2017
Source: The Royal Society
Permalink: http://www.makingmalariahistory.org/toolkit-resource/characterizing-and-quantifying-human-movement-patterns-using-gps-data-loggers-in-an-area-approaching-malaria-elimination-in-rural-southern-zambia/