Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood

A mother’s infection with placental malaria (PM) can affect her child’s susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a small amount of maternal cells and DNA known as maternal microchimerism (MMc), and it was hypothesized that PM increases MMc and that MMc alters risk of Plasmodium falciparum malaria during infancy. Here, the presence and level of cord blood MMc in offspring of women with and without PM was evaluated.

Author: , , , , , , ,
Publication date: March 2017
Source: The Journal of Infectious Diseases
Permalink: http://www.makingmalariahistory.org/toolkit-resource/maternal-microchimerism-predicts-increased-infection-but-decreased-disease-due-to-plasmodium-falciparum-during-early-childhood/

Pregnant women and infants as sentinel populations to monitor prevalence of malaria: results of pilot study in Lake Zone of Tanzania

This pilot explored the feasibility and utility of tracking the prevalence of malaria infection in pregnant women attending their first antenatal care (ANC) visit and infants presenting at 9–12 months of age for measles vaccination as possible sentinel populations to monitor changes in malaria prevalence.

Author: , , , , , , , , , , , , , , ,
Publication date: July 2016
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/pregnant-women-and-infants-as-sentinel-populations-to-monitor-prevalence-of-malaria-results-of-pilot-study-in-lake-zone-of-tanzania/

Investing in Malaria in Pregnancy in Sub-Saharan Africa: Saving Women’s and Children’s Lives

An infographic developed by RBM’s Malaria in Pregnancy Working Group to address the need for key facts on MiP and high level talking points targeting MoH policy makers and managers.

Author:
Publication date: April 2016
Source: Roll Back Malaria
Permalink: http://www.makingmalariahistory.org/toolkit-resource/investing-in-malaria-in-pregnancy-in-sub-saharan-africa-saving-womens-and-childrens-lives/

Exposure to artemether-lumefantrine (Coartem®) in first trimester pregnancy in an observational study in Zambia

Pregnant women who were exposed to artemether-lumefantrine (AL) for the treatment of uncomplicated malaria were followed up and evaluated in a prospective cohort study. This report assessed the longitudinal safety outcomes of the pregnant women inadvertently exposed during the first trimester. Exposure was not associated with particular safety risks, suggesting that randomized clinical trials could now be the way forward to assess safety and efficacy of ACT in the first trimester of pregnancy.

Author: , , , , ,
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/exposure-to-artemether-lumefantrine-coartem-in-first-trimester-pregnancy-in-an-observational-study-in-zambia/

Caregivers’ treatment-seeking behaviour for children under age five in malaria-endemic areas of rural Myanmar: a cross-sectional study

A community-based malaria intervention was introduced through fixed and mobile clinics in rural Myanmar. This study attempted to identify treatment-seeking behaviour of caregivers for children under five and the determinants of appropriate treatment-seeking behaviour in mobile clinic villages (MV) and non-mobile clinic villages (NMV) in malaria-endemic rural areas in Myanmar.

Author: , , ,
Publication date: January 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/caregivers-treatment-seeking-behaviour-for-children-under-age-five-in-malaria-endemic-areas-of-rural-myanmar-a-cross-sectional-study/

Disparities of Plasmodium falciparum infection, malaria-related morbidity and access to malaria prevention and treatment among school-aged children: a national cross-sectional survey in Côte d’Ivoire

There is limited knowledge on the malaria burden of school-aged children in Côte d’Ivoire. The aim of this study was to assess Plasmodium falciparum infection, malaria-related morbidity, use of preventive measures and treatment against malaria, and physical access to health structures among school-aged children across Côte d’Ivoire.

Author: , , , , , , , , , , , , ,
Publication date: January 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/disparities-of-plasmodium-falciparum-infection-malaria-related-morbidity-and-access-to-malaria-prevention-and-treatment-among-school-aged-children-a-national-cross-sectional-survey-in-cote-d/

Pregnant women are a reservoir of malaria transmission in Blantyre, Malawi

These data suggest that pregnant women are a significant reservoir of gametocyte transmission and should not be overlooked in elimination efforts. Interventions targeting this population would benefit from reaching women prior to first antenatal visit.

Author: , , , , , , ,
Publication date: December 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/pregnant-women-are-a-reservoir-of-malaria-transmission-in-blantyre-malawi/

Coverage and efficacy of intermittent preventive treatment with sulphadoxine pyrimethamine against malaria in pregnancy in Côte d’Ivoire five years after its implementation.

This study found relative low coverage of IPTp in the study areas which supported findings that high ANC attendance does not guarantee high IPTp coverage. Urgent efforts are required to improve service delivery of this important intervention.

Author: , , , , , , , , , , , , , , ,
Publication date: November 2014
Source: Parasites & Vectors
Permalink: http://www.makingmalariahistory.org/toolkit-resource/coverage-and-efficacy-of-intermittent-preventive-treatment-with-sulphadoxine-pyrimethamine-against-malaria-in-pregnancy-in-cote-divoire-five-years-after-its-implementation/

Malaria prevention and treatment in pregnancy: Survey of current practice among private medical practitioners in Lagos, Nigeria

The study showed that private medical practitioners have poor knowledge of malaria prophylaxis and treatment in pregnancy, and the practice of most do not conform to recommended guidelines.

Author: , , , , , ,
Publication date: September 2014
Source: Tropical Doctor
Permalink: http://www.makingmalariahistory.org/toolkit-resource/malaria-prevention-and-treatment-in-pregnancy-survey-of-current-practice-among-private-medical-practitioners-in-lagos-nigeria/

Cost-effectiveness of dihydroartemisinin-piperaquine compared with artemether-lumefantrine for treating uncomplicated malaria in children at a district hospital in Tanzania

Dihydroartemisinin-piperaquine (DhP) is highly recommended for the treatment of uncomplicated malaria. This study aims to compare the costs, health benefits and cost-effectiveness of DhP and artemether-lumefantrine (AL) alongside “do-nothing” as a baseline comparator in order to consider the appropriateness of DhP as a first-line anti-malarial drug for children in Tanzania.

Author: , , ,
Publication date: September 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/cost-effectiveness-of-dihydroartemisinin-piperaquine-compared-with-artemether-lumefantrine-for-treating-uncomplicated-malaria-in-children-at-a-district-hospital-in-tanzania/