Persistence of sulfadoxine-pyrimethamine resistance despite reduction of drug pressure in Malawi

In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. This study estimates the effect of reduced SP drug pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci.

Author: , , , , , , , ,
Publication date: February 2015
Source: The Journal of Infectious Diseases

A cohort study of the effectiveness of insecticide-treated bed nets to prevent malaria in an area of moderate pyrethroid resistance, Malawi

Insecticide-treated bed nets (ITNs) are the cornerstone of malaria control in sub-Saharan Africa but their effectiveness may be compromised by the spread of pyrethroid resistance among malaria vectors. The objective of this investigation was to assess the effectiveness of ITNs to prevent malaria in an area of Malawi with moderate pyrethroid resistance.

Author: , , , , , , , , , , , ,
Publication date: January 2015
Source: Malaria Journal