Primaquine: the risks and the benefits

Review of dose-response relationships and clinical trials of primaquine in G6PD deficiency suggests that the currently recommended WHO single low dose (0.25 mg base/kg) to block falciparum malaria transmission confers a very low risk of haemolytic toxicity.

Author: , ,
Publication date: November 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/primaquine-the-risks-and-the-benefits/

Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections

A study on the efficacy of tafenoquine compared to primaquine on treating malaria infections when given orally to mice.

Author: , ,
Publication date: April 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/assessment-of-the-prophylactic-activity-and-pharmacokinetic-profile-of-oral-tafenoquine-compared-to-primaquine-for-inhibition-of-liver-stage-malaria-infections/

Implementation of low dose primaquine as a gametocytocide in sub-Saharan Africa

A report that assesses opportunities and challenges for rolling out low-dose primaquine in sub-Saharan Africa, evaluating the current supply and production of primaquine, assessing country willingness to deploy low-dose primaquine, and identifying key barriers to implementation.

Author: , ,
Publication date: October 2013
Source: UCSF Global Health Sciences
Permalink: http://www.makingmalariahistory.org/toolkit-resource/implementation-of-low-dose-primaquine-as-a-gametocytocide-in-sub-saharan-africa/

Rationale for short course primaquine in Africa to interrupt malaria transmission

A report of a meeting held in London in March 2012, discussing the existing evidence on the ability of primaquine to block malaria transmission, defining the roadblocks to the use of primaquine in Africa and to developing a roadmap to enable its rapid, safe and effective deployment.

Author: , ,
Publication date: October 2012
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/rationale-for-short-course-primaquine-in-africa-to-interrupt-malaria-transmission/