The return of chloroquine-susceptible Plasmodium falciparum malaria in Zambia

The study found the disappearance of chloroquine-resistant malaria after the removal of chloroquine drug pressure. Chloroquine may have a role for malaria prevention or treatment in Zambia and throughout the region in the future.

Author: , , , , , , , , ,
Publication date: December 2016
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/the-return-of-chloroquine-susceptible-plasmodium-falciparum-malaria-in-zambia/

Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia

This article details the major advances in the current understanding of resistance to artemisinin and piperaquine and defines the challenges that the malaria community will have to face in the coming years.

Author: , ,
Publication date: December 2016
Source: The American Journal of Tropical Medicine and Hygiene
Permalink: http://www.makingmalariahistory.org/toolkit-resource/plasmodium-falciparum-resistance-to-artemisinin-derivatives-and-piperaquine-a-major-challenge-for-malaria-elimination-in-cambodia/

Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi

As one of the first African countries to switch from chloroquine to sulfadoxine/pyrimethamine (SP) in 1993, and the last to switch from SP to ACT in 2007, Malawi stands out from the rest of Africa in having a significantly prolonged exposure to SP. This study reports the persistence of genetic variants associated with SP and chloroquine resistance within the P. falciparum population in Malawi, despite withdrawal of these anti-malarials from front-line use.

Author: , , , , , , , , , , , , , ,
Publication date: November 2016
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/roles-and-challenges-of-construction-firms-and-public-health-entomologists-in-ending-indoor-malaria-transmission-in-african-setting/

Lessons Learned from Fifteen Years of Responding to Malaria Globally: A Prototype for Sustainable Development

This briefing paper, compiled by Roll Back Malaria’s Messaging Workstream, outlines malaria’s potential contribution to the Sustainable Development Goals, demonstrating the links between malaria investment and progress in other development areas.

Author:
Publication date: September 2015
Source: Roll Back Malaria
Permalink: http://www.makingmalariahistory.org/toolkit-resource/lessons-learned-from-fifteen-years-of-responding-to-malaria-globally-a-prototype-for-sustainable-development/

Parasite clearance after malaria therapy: staying a step ahead of drug resistance

The Worldwide Antimalarial Resistance Network have analysed data from 29,493 patients from 84 clinical trials in order to define the nature and determinants of early parasite clearance following artemisinin-based treatment in African populations. In doing so, they lay the foundation for systems intended to enable the earliest possible detection of emerging artemisinin resistance in Africa.

Author:
Publication date: September 2015
Source: BMC Medicine
Permalink: http://www.makingmalariahistory.org/toolkit-resource/parasite-clearance-after-malaria-therapy-staying-a-step-ahead-of-drug-resistance/

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs).

Author:
Publication date: September 2015
Source: BMC Medicine
Permalink: http://www.makingmalariahistory.org/toolkit-resource/clinical-determinants-of-early-parasitological-response-to-acts-in-african-patients-with-uncomplicated-falciparum-malaria-a-literature-review-and-meta-analysis-of-individual-patient-data/

Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation

The impact of insecticide resistance on the protective effectiveness of insecticide-treated nets (ITN) and indoor residual spraying (IRS) is not known. A multi-country study was undertaken in Sudan, Kenya, India, Cameroon and Benin to quantify the potential loss of epidemiological effectiveness of ITNs and IRS due to decreased susceptibility of malaria vectors to insecticides.

Author: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: July 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/design-of-a-study-to-determine-the-impact-of-insecticide-resistance-on-malaria-vector-control-a-multi-country-investigation/

Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation

The impact of insecticide resistance on the protective effectiveness of insecticide-treated nets (ITN) and indoor residual spraying (IRS) is not known. A multi-country study was undertaken in Sudan, Kenya, India, Cameroon and Benin to quantify the potential loss of epidemiological effectiveness of ITNs and IRS due to decreased susceptibility of malaria vectors to insecticides. The paper discusses challenges faced in the design and execution of the study, the analysis plan, the strengths and weaknesses, and the possible alternatives to the chosen study design.

Author: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: July 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/design-of-a-study-to-determine-the-impact-of-insecticide-resistance-on-malaria-vector-control-a-multi-country-investigation-2/

Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.

Author: , , , , , , , , , ,
Publication date: July 2015
Permalink: http://www.makingmalariahistory.org/toolkit-resource/past-and-new-challenges-for-malaria-control-and-elimination-the-role-of-operational-research-for-innovation-in-designing-interventions/

Evidence of falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label multicenter clinical assessment.

The data from this study support evidence of P. falciparum piperaquine resistance in western Cambodia, an area of widespread artemisinin resistance. The study recommends that new therapeutic strategies be tested, such as the use of triple ACTs.

Author: , , , , , , , , , , , ,
Publication date: May 2015
Source: American Society for Microbiology
Permalink: http://www.makingmalariahistory.org/toolkit-resource/evidence-of-falciparum-malaria-multidrug-resistance-to-artemisinin-and-piperaquine-in-western-cambodia-dihydroartemisinin-piperaquine-open-label-multicenter-clinical-assessment/