Tackling Imported Malaria: An Elimination Endgame

Cross border and regional initiatives can be highly effective when based on an understanding of human and parasite movement. Ultimately, determining the optimal combinations of approaches to address malaria importation will require an evaluation of their impact, cost effectiveness, and operational feasibility.

Author: , , , ,
Publication date: May 2015
Source: AJTMH
Permalink: http://www.makingmalariahistory.org/toolkit-resource/tackling-imported-malaria-an-elimination-endgame/

Maximizing antimalarial efficacy and the importance of dosing strategies

An analysis of clinical trials of artesunate-amodiaquine, widely used among children in Africa, revealed a superior efficacy for fixed-dose combination tablets compared to loose non-fixed dose combinations. This highlights the benefits of fixed-dose combinations as a practical strategy for ensuring optimal antimalarial dosing and maximizing efficacy.

Author: , ,
Publication date: May 2015
Source: BMC Medicin
Permalink: http://www.makingmalariahistory.org/toolkit-resource/maximizing-antimalarial-efficacy-and-the-importance-of-dosing-strategies/

Molecular Surveyor K13

The discovery of molecular markers of resistance in the Kelch 13 gene gives us the unusual opportunity to monitor the emergence and spread of resistance nearly in real time. The K13 Molecular Surveyor is an interactive map that summarises the prevalence of these molecular markers in the propeller region of the Kelch 13 gene of the malaria parasite by location and year, providing a clear and standardised visualisation of the evidence to date to inform key international, regional and national monitoring strategies.

Publication date: May 2015
Source: Worldwide Antimalarial Resistance Network (WWARN)
Permalink: http://www.makingmalariahistory.org/toolkit-resource/molecular-surveyor-k13/

Malaria vectors resistance to insecticides in Benin: current trends and mechanisms involved

The present study reveals observed insecticide resistance trends in Benin to help for a better management of insecticide resistance.

Author: , , , , , , , , , , , ,
Publication date: April 2015
Source: Parasites and Vectors
Permalink: http://www.makingmalariahistory.org/toolkit-resource/malaria-vectors-resistance-to-insecticides-in-benin-current-trends-and-mechanisms-involved/

Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign

This study demonstrates that parasites with K13 propeller mutations associated with artemisinin resistance were widely present along the Thai-Cambodia and Thai-Myanmar borders prior to the implementation of the artemisinin resistance containment project in the region.

Author: , , , , , , , , , ,
Publication date: April 2015
Source: PLOS Pathogens
Permalink: http://www.makingmalariahistory.org/toolkit-resource/selection-and-spread-of-artemisinin-resistant-alleles-in-thailand-prior-to-the-global-artemisinin-resistance-containment-campaign/

Clinical Efficacy of Dihydroartemisinin–Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China–Myanmar Border

This study was conducted from March 2012 to December 2013 in four clinics and seven villages along the China–Myanmar border. The presence of gametocytes in patients through 14 days after DHA-P treatment suggests that the incorporation of a single dose of primaquine for clearing gametocytemia should be considered for blocking parasite transmission.

Author: , , , , , , , , , ,
Publication date: March 2015
Source: AJTMH
Permalink: http://www.makingmalariahistory.org/toolkit-resource/clinical-efficacy-of-dihydroartemisinin-piperaquine-for-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-at-the-china-myanmar-border/

UNITAID Malaria Medicines Landscape

A review of the current and pipeline medicines for malaria, highlighting a strong research and development pipeline with new options emerging for P. vivax, single dose treatments, paediatric formulations, and more options for chemoprevention. It also highlights the opportunities to make these new products more widely available such as through market entry support, sharing information on artemisinin supply and demand, and supporting a competitive market for child-friendly ACT formulations.

Publication date: March 2015
Permalink: http://www.makingmalariahistory.org/toolkit-resource/unitaid-malaria-medicines-landscape/

Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers

As efforts to contain artemisinin resistance and eliminate Plasmodium falciparum intensify, the accurate diagnosis and prompt effective treatment of malaria are increasingly needed in Myanmar and the Greater Mekong Sub-region (GMS). This study tested different incentives to increase RDT use and improve the quality of care among informal private healthcare providers in Myanmar.

Author: , , , , , , , , ,
Publication date: March 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/improving-uptake-and-use-of-malaria-rapid-diagnostic-tests-in-the-context-of-artemisinin-drug-resistance-containment-in-eastern-myanmar-an-evaluation-of-incentive-schemes-among-informal-private-healt/

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

Emergence of artemisinin resistance in Southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Currently, artemisinin resistance extends across much of Myanmar. P falciparum parasites carrying K13-propeller mutations were recorded at high prevalence next to the northwestern border with India. Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of artemisinin resistance to other regions is to be avoided.

Author: , , , , , , , , , , , , , , , , , , , , , , , , , ,
Publication date: February 2015
Source: The Lancet Infectious Diseases
Permalink: http://www.makingmalariahistory.org/toolkit-resource/spread-of-artemisinin-resistant-plasmodium-falciparum-in-myanmar-a-cross-sectional-survey-of-the-k13-molecular-marker/

Persistence of sulfadoxine-pyrimethamine resistance despite reduction of drug pressure in Malawi

In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. This study estimates the effect of reduced SP drug pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci.

Author: , , , , , , , ,
Publication date: February 2015
Source: The Journal of Infectious Diseases
Permalink: http://www.makingmalariahistory.org/toolkit-resource/persistence-of-sulfadoxine-pyrimethamine-resistance-despite-reduction-of-drug-pressure-in-malawi/