Infection importation: a key challenge to malaria elimination on Bioko Island, Equatorial Guinea

A study examining the impact of importation of falciparum malaria from mainland Equatorial Guinea on malaria infection in non-travellers and travelers on Bioko Island. Malaria importation by travelers was found to pose a serious public health challenge, affecting non-travellers as well as travellers.

Author: , , , , , , , ,
Publication date: February 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/infection-importation-a-key-challenge-to-malaria-elimination-on-bioko-island-equatorial-guinea/

A cohort study of the effectiveness of insecticide-treated bed nets to prevent malaria in an area of moderate pyrethroid resistance, Malawi

Insecticide-treated bed nets (ITNs) are the cornerstone of malaria control in sub-Saharan Africa but their effectiveness may be compromised by the spread of pyrethroid resistance among malaria vectors. The objective of this investigation was to assess the effectiveness of ITNs to prevent malaria in an area of Malawi with moderate pyrethroid resistance.

Author: , , , , , , , , , , , ,
Publication date: January 2015
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/a-cohort-study-of-the-effectiveness-of-insecticide-treated-bed-nets-to-prevent-malaria-in-an-area-of-moderate-pyrethroid-resistance-malawi/

Human-to-mosquito transmission efficiency increases as malaria is controlled

The efficiency of malaria transmission between human and mosquito has been shown to be influenced by many factors in the laboratory, although their impact in the field and how this changes with disease endemicity are unknown. This study estimates how human–mosquito transmission changed as malaria was controlled in Dielmo, Senegal. Results show that asexual parasite slide prevalence in humans has reduced from 70 to 20%, but that the proportion of infectious mosquitoes has remained roughly constant.

Author: , ,
Publication date: January 2015
Source: Nature
Permalink: http://www.makingmalariahistory.org/toolkit-resource/human-to-mosquito-transmission-efficiency-increases-as-malaria-is-controlled/

Artemisinin resistance – modelling the potential human and economic costs

Artemisinin resistance poses a huge threat to the successes of malaria control in the past decade. This study quantifies the risks – providing estimates on how much additional mortality and health care costs to expect.

Author: , , , , , , , ,
Publication date: November 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/artemisinin-resistance-modelling-the-potential-human-and-economic-costs/

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies.

Author: , , , , , , , , , , , , , , , , ,
Publication date: July 2014
Source: New England Journal of Medicine
Permalink: http://www.makingmalariahistory.org/toolkit-resource/spread-of-artemisinin-resistance-in-plasmodium-falciparum-malaria/

The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion

Foci of artemisinin drug resistance have been identified in the Greater Mekong subregion (GMS) of the Asia Pacific, threatening the major gains made in malaria control and potentially creating a parasite pool that is more difficult to treat and eliminate. … A sustainable solution is the rapid elimination of all Plasmodium falciparum parasites from the GMS.

Author: , , , , , , ,
Publication date: July 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/the-challenge-of-artemisinin-resistance-can-only-be-met-by-eliminating-plasmodium-falciparum-malaria-across-the-greater-mekong-subregion/

The development of behaviour change interventions to support the use of malaria rapid diagnostic tests by Tanzanian clinicians

Simply making RDTs available has not led to high uptake of the tests or adherence to results by clinicians, with malaria continuing to be overdiagnosed in many settings. This article proposes an evidence-based intervention package that would be sufficient to support the introduction of RDTs at dispensaries in Tanzania, to be evaluated through the Targeting Artemisinin Combination Therapy (TACT) cluster randomised controlled trial.

Author: , , , , , , ,
Publication date: June 2014
Source: Implementation Science
Permalink: http://www.makingmalariahistory.org/toolkit-resource/the-development-of-behaviour-change-interventions-to-support-the-use-of-malaria-rapid-diagnostic-tests-by-tanzanian-clinicians/

Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia

A study examining the efficacy of IPTp-SP and the presence of the quintuple mutant hapolyte among pregnant women in Mansa, Zambia.

Author: , , , , , , , , , ,
Publication date: June 2014
Source: Malaria Journal
Permalink: http://www.makingmalariahistory.org/toolkit-resource/efficacy-of-sulphadoxine-pyrimethamine-for-intermittent-preventive-treatment-of-malaria-in-pregnancy-mansa-zambia/

Emergence and spread of artemisinin resistance calls for intensified efforts to withdraw oral artemisinin-based monotherapy from the market

A report calling for intensified action to withdraw oral artemisinin-based monotherapy from the market and to promote the use of artemisinin-based combination therapy, in order to protect against further artemisinin resistance.

Author:
Publication date: May 2014
Source: World Health Organization
Permalink: http://www.makingmalariahistory.org/toolkit-resource/emergence-and-spread-of-artemisinin-resistance-calls-for-intensified-efforts-to-withdraw-oral-artemisinin-based-monotherapy-from-the-market/

Emergence and spread of artemisinin resistance calls for intensified efforts to withdraw oral artemisinin-based monotherapy from the market

An update on the latest status report on artemisinin resistance, providing an overview of WHO’s recommended regulatory actions and country progress to date to withdraw oral artemisinin-based monotherapy (oAMT) from the market.

Author:
Publication date: May 2014
Source: World Health Organization
Permalink: http://www.makingmalariahistory.org/toolkit-resource/emergence-and-spread-of-artemisinin-resistance-calls-for-intensified-efforts-to-withdraw-oral-artemisinin-based-monotherapy-from-the-market-2/