In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. This study estimates the effect of reduced SP drug pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci.
Author: Artimovich E, Dzinjalamala FK, Escalante AA, Kublin JG, Laufer M, Plowe CV, Schneider K, Takala-Harrison S, Taylor T
Publication date: February 2015
Source: The Journal of Infectious Diseases